Kodi maselo ndi maselo a chitetezo cha mthupi angayankhire bwanji mwamsanga kusintha kwa thupi ndi mankhwala m'malo awo?
Ngakhale kusintha kwa ma genetic kungayambitse kusintha kwa maselo, njira zopanda chibadwa zimatha kuyendetsa kusintha mwachangu, mwanjira yomwe imatchedwa cell plasticity. Cell plasticity imakhudzidwa ndi njira zoyambira zamoyo umoyo ndi matenda. Mwachitsanzo, ma cell a chotupa amatha kuchoka kumalo ochulukirachulukira kupita kumalo ovuta kwambiri, motero amalimbikitsa metastasis ya khansa. Kumbali ina, panthawi yotupa, maselo a chitetezo cha mthupi amatha kusintha kukhala maselo omwe amachititsa kutupa ndikulimbikitsa kukonza minofu. Kutupa kosalamulirika komwe kumachoka m'manja kungayambitse kuwonongeka kwa minofu ndipo pamapeto pake kugwedezeka kwa septic.
Gulu la Institut Curie ku Paris tsopano linapeza wolakwa watsopano wa njirazi pa mlingo wa maselo; ntchito yomwe idasindikizidwa posachedwa m'magazini yasayansi Nature.
Ofufuzawa adapeza kuti maselo omwe amachititsa kuti metastasis apangidwe kapena maselo a chitetezo chamthupi omwe amakhudzidwa ndi kutupa ndi kukayikira kukayikira awonjezera kuchuluka kwa mkuwa, womwe umayambitsa kusintha kwa cell plasticity. Chochititsa chidwi n'chakuti mkuwa umatengedwa kupita ku maselo kudzera mu mapuloteni otchedwa CD44 ndi hyaluronic acid, omwe amadziwikanso kuti ndi opangira zinthu zambiri zokongola. Panali kale umboni wa kutengedwa kwachitsulo ndi CD44 m'maselo a khansa ndi gulu lofufuza, lofalitsidwa kale mu magazini Chemistry Zachilengedwe. CD44 ndi mapuloteni omwe akhala akuphunziridwa kwambiri kwa zaka zambiri ndipo amapezeka m'maselo ambiri, kuphatikizapo maselo a chitetezo cha mthupi, maselo a khansa, maselo okhudzidwa ndi machiritso a zilonda, maselo obadwa nawo a maselo ofiira a magazi ndi zina zambiri. Asayansi adawonetsa kuti mkuwa womwe umatengedwa ndi CD44 umadziunjikira mu mitochondria ya maselo, omwe ndi organelles omwe amagwira ntchito yopanga mphamvu.
Ntchito yowonjezereka ya apolisi yofufuza njira zofunika kwambiri zapangitsa kuti mkuwa uwongolere kagayidwe kake mu mitochondria, mwachitsanzo, umakhudza mwachindunji kupanga mphamvu kwa selo. Izi zimasinthanso mamolekyu otchedwa metabolites, omwe amakhudza momwe majini amawerengedwera mu selo. Makamaka milingo ya NAD (H) idakhudzidwa, yomwe ndi imodzi mwazinthu zodziwika bwino komanso zofunika kwambiri za metabolites zomwe zimadziwika m'maselo amunthu. Mwachidule, kusinthaku kumakhala ndi zotsatira zomwe selo lingathe kuchita ndikuwoneka komanso kukhudza ntchito yake.
Kuphatikiza apo, asayansi adapanga kamphindi kakang'ono katsopano mankhwala-monga molekyulu, yochokera ku metformin yolimbana ndi matenda a shuga, yomwe imatha kuletsa njirazi pomanga ndi kuyambitsa mkuwa uwu. Izi zimathandizira kupanga mphamvu kwa selo ndipo pamapeto pake ntchito yake. Pankhani ya ma cell a chitetezo chamthupi, ofufuzawo atha kukwaniritsa ma cell omwe ali ndi chitetezo chamthupi komanso kuchepetsa kutupa mumitundu ya mbewa. Mankhwala atsopanowa amatha kupulumutsa mbewa za septic shock.
Koma sizinali zokhazo. Kafukufukuyu adawonetsanso kuti njira zazikuluzikulu zomwe zimayambitsa kutupa zimapezekanso mu khansa, makamaka m'maselo omwe amatha kuyambitsa metastasis! Chifukwa chake, njira iyi ikhoza kugwiritsidwa ntchito polimbana ndi metastasis. Popeza anthu opitilira 11 miliyoni amafa ndi vuto la septic padziko lonse lapansi pachaka ndipo 90% ya kufa kwa khansa kumachitika chifukwa cha metastases, pali chiyembekezo chachikulu kuti izi zitha kupangidwa kukhala mankhwala atsopano, omwe angathandize odwala ambiri padziko lonse lapansi.
Ponseponse, kafukufukuyu tsopano akuwonetsa lonjezano lalikulu, pamlingo wofunikira wa kafukufuku wama cell komanso momwe angagwiritsire ntchito zachipatala. Zimatipatsanso funso lakuti kodi mkuwa ndi wabwino bwanji kwa ife?
Chitsime: Institut Curie
