Ha litekanyetso tse tlase tsa lithethefatsi tsa mofets'e li ntse li fanoa khafetsa haufi le lihlahala tse kotsi tsa boko ho sebelisoa seo ho thoeng ke theknoloji ea iontronic, kholo ea lisele tsa mofetše e fokotseha haholo.
Bafuputsi ba Univesithi ea Linköping le Univesithi ea Bongaka ea Graz ba bontšitse sena litekong tsa mahe a linonyana. Liphetho ke mohato o le mong o haufi le mefuta e mecha ea kalafo e sebetsang bakeng sa mefuta e matla ea mofetše.
Hangata lihlahala tse kotsi bokong li ipheta ho sa tsotellehe ho buuoa le ka mor'a ho phekoloa ka chemotherapy le mahlaseli. Sena se bakoa ke hore lisele tsa mofetše li ka "pata" ka har'a lisele ebe li hola hape. Lithethefatsi tse sebetsang ka ho fetisisa li ke ke tsa feta ho seo ho thoeng ke thibelo ea mali-boko - marang-rang a thata a potolohileng methapo ea mali bokong e thibelang lintho tse ngata tse maling ho kena ho eona. Ka lebaka leo, ho na le likhetho tse fokolang tse fumanehang bakeng sa ho phekola lihlahala tse matla tsa boko.
Ka 2021, sehlopha sa lipatlisiso se tsoang Univesithing ea Linköping le Univesithi ea Bongaka ea Graz li bontšitse kamoo pompo ea iontronic e ka sebelisoang ho fana ka lithethefatsi sebakeng sa heno le ho thibela kholo ea lisele bakeng sa mofuta o kotsi le o mabifi oa mofetše oa boko - glioblastoma. Ka nako eo, liteko li ne li etsoa ka lisele tsa tumor ka sejana sa petri.
Khopolo e netefalitsoeng
Hona joale, sehlopha se tšoanang sa lipatlisiso se nkile mohato o latelang oa ho sebelisa theknoloji ena kalafong ea mofetše oa bongaka. Ka ho lumella lisele tsa glioblastoma hore li hole li sebelisa mahe a linonyana a sa ntlafatsoang, mekhoa e mecha ea kalafo e ka lekoa lihlahala tse phelang. Bafuputsi ba bontšitse hore kholo ea tsoaroa ke kankere lisele li fokotsehile ha litekanyetso tse tlaase tsa lithethefatsi tse matla (gemcitabine) li tsoela pele ho sebelisoa ho sebelisoa pompo ea iontronic e haufi le hlahala ea boko.
"Re kile ra bonts'a hore mohopolo ona oa sebetsa. Hona joale re sebelisa mohlala o nang le hlahala e phelang, 'me re ka bona hore pompo e tsamaisa lithethefatsi ka katleho haholo. Kahoo le hoja e le mohlala o nolofalitsoeng oa motho, re ka bua ka kholiseho e khōloanyane hore oa sebetsa,” ho bolela Daniel Simon, moprofesa oa organic electronics Univesithing ea Linköping.
Khopolo ea kalafo ea kamoso ea glioblastoma e kenyelletsa ho kenya sesebelisoa sa iontronic ka ho toba bokong, haufi le hlahala. Mokhoa ona o lumella tšebeliso ea litekanyetso tse tlase tsa lithethefatsi tse matla ha ho ntse ho feta mokoallo oa mali le boko. Dosing e nepahetseng, ho latela sebaka le nako, e bohlokoa bakeng sa kalafo e sebetsang. Ho feta moo, mokhoa ona o ka fokotsa litla-morao kaha chemotherapy ha e hloke ho potoloha 'mele oohle.
Kalafo ea mefuta e fapaneng ea mofetše
Ka ntle ho lihlahala tsa boko, bafuputsi ba tšepa hore iontronics e ka sebelisoa mefuteng e mengata ea mefuta ea mofetše eo ho leng thata ho e phekola.
E fetoha phekolo e phehellang haholo eo hlahala e ke keng ea ipata ho eona. Leha hlahala le lisele tse haufi li leka ho tlosa sethethefatsi sena, lisebelisoa le lits'ebetso tsa taolo tseo re li sebelisang ho iontronics li ka tsoela pele ho fana ka meriana e ngata sebakeng sa heno e haufi le hlahala, "ho hlalosa Theresia Arbring Sjöström, mofuputsi Laboratoring. Organic Electronics Univesithing ea Linköping.
Bafuputsi ba ile ba bapisa phepelo e tsoelang pele ea lithethefatsi ea pompo le dosing hang ka letsatsi, e ts'oanang haholo le tsela eo chemotherapy e tsamaisoang ka eona ho bakuli kajeno. Ba hlokometse hore ho hōla ha hlahala ho fokotsehile ka phekolo ea ionic empa eseng ka mokhoa oa letsatsi le letsatsi, le hoja e ne e le matla habeli.
Ho hlokahala lipatlisiso tse ling
Liteko tsena li entsoe ho sebelisoa mahe a emolisitsoeng a linonyana qalong ea tsoelo-pele. Ho ea ka Linda Waldherr, mofuputsi Univesithing ea Bongaka ea Graz le mofuputsi oa moeti oa LiU, mohlala ona o sebetsa e le borokho bo botle ba liteko tse kholoanyane tsa liphoofolo:
“Mahe a linonyana a emolisitsoeng, tsamaiso e itseng ea likokoana-hloko e sebetsa ka tsela e tšoanang le ea liphoofolo tse phelang, tse kang ho thehoa ha methapo ea mali. Leha ho le joalo, ha ho hlokahale hore re kenye lisebelisoa leha e le life ho tsona ka ho buuoa. Sena se bontša hore mohopolo ona oa sebetsa, leha ho ntse ho e-na le liqholotso tse ngata tse lokelang ho rarolloa, ”o rialo.
Bafuputsi ba lumela hore liteko tsa batho li ka khonahala nakong ea lilemo tse hlano ho isa ho tse leshome tse tlang. Mehato e latelang e kenyelletsa lisebelisoa tse tsoelang pele tse ntlafatsang ho lumella ho kenngoa ha opereishene ea lipompo tsa iontronic. Ho tla boela ho etsoe liteko tse latelang ho likhoto le liphoofolo tse khōloanyane ho tsoela pele ho hlahloba mokhoa ona oa phekolo.
Boithuto bona bo tšehelitsoe ka lichelete haholo ke Austrian Science Fund, European Union's Horizon Europe lenaneo, Seswedishe Foundation for Strategic Research, the Knut le Alice Wallenberg Foundation le European Research Council. Theresia Arbring Sjöström, Tobias Abrahamsson, Magnus Berggren le Daniel Simon ke ba nang le kabelo k'hamphaning ea OBOE IPR AB e nang le litokelo tsa molao tse amanang le theknoloji ea iontronic.
Article: Iontronic Chemotherapy e Tsoelang Pele e Fokotsa Khōlo ea Tumor ea Boko ho Embryonic Avian in vivo Models, Verena Handl, Linda Waldherr, Theresia Arbring Sjöström, Tobias Abrahamsson, Maria Seitanidou, Sabine Erschen, Astrid Gorischek, Iwona Bernacka Wojcik, Helena Saarela, Tamara Tomin, Sophie Elisabeth Honeder, Joachim Distl, Martin AsslaberGürner , Ute Schäfer, Magnus Berggren, Rainer Schindl, Silke Patz, Daniel T. Simon, Nassim Ghaffari-Tabrizi-Wizsy; Journal of Controlled Release; e phatlalalitsoe inthaneteng ka la 11 Mmesa 2024. DOI: 10.1016/j.jconrel.2024.03.044
E ngotsoe ke Anders Törneholm
