Hauv kev tshawb fawb koom tes ntawm King Abdullah University of Science thiab Technology (KAUS), King Abdulaziz University, Jeddah (KAUG) thiab King Abdulaziz University Tsev Kho Mob, Jeddah (KAUH), cov kws tshawb fawb tau ua kev tshawb fawb thawj zaug hauv lub Nceeg Vaj ntawd piv cov qia hlwb muab los ntawm ib tug tshwj xeeb cohort ntawm Saudi Klinefelter cov neeg mob nrog ib pab pawg neeg ntawm North American thiab European qhovntsej thiaj tsis mob.
Lub teratoma yog ib qho qog embryonal tsim los ntawm pluripotent qia hlwb. Hauv chav kuaj, KAUST cov kws tshawb fawb siv Teratoma tsim kev ntsuam xyuas los ua pov thawj tias tus neeg mob tau txais iPSCs yog pluripotent tiag tiag. Image credit: KAUS
Klinefelter yog ib qho kab mob chromosomal uas tshwm sim los ntawm ib qho ntxiv chromosome X hauv cov hlwb ntawm cov txiv neej. Cov tsos mob tsis tu ncua ntawm tus mob no yog infertility, kev txawj ntse tsis muaj peev xwm, metabolic syndrome thiab hom 2 mob ntshav qab zib, thiab ib ntawm txhua rau pua tus txiv neej Saudi raug cuam tshuam.
Txawm li cas los xij, MENA cov pej xeem tsis tshua muaj neeg sawv cev thaum kawm txog qhov cuam tshuam ntawm keeb kwm genomic ntawm tus kab mob susceptibility thiab prognosis. Feem ntau ntawm kev tshawb fawb txog kev siv iPSCs tau ua los ntawm North American thiab European cov neeg mob.
Txoj kev tshawb fawb KAUST-KAU-HAUH hais txog qhov sib txawv no siv "tus neeg mob-los ntawm induced pluripotent stem cells" (iPSC)-based kab mob kev tshawb fawb kom nkag siab txog lub hauv paus molecular ntawm Klinefelter syndrome. Los ntawm kev siv cov tawv nqaij, ntshav, plaub hau lossis cov zis tso zis ntawm tes nrog iPSC txoj hauv kev, nws muaj peev xwm coj tus neeg mob lub hlwb rov qab mus rau lub embryonic lub xeev uas lawv tau tsim, thiab siv lawv los ua qauv kev pib thiab kev loj hlob ntawm cov kab mob "hauv ib qho tais."
"Lub Nceeg Vaj tau txais txiaj ntsig los ntawm kev sib koom tes hauv ntiaj teb ntawm peb lub koom haum tshawb fawb," said Vice President for Research. Pierre Magistretti, Distinguished Professor thiab tus thawj coj ntawm KAUST Smart-Health Initiative. "Lub thev naus laus zis iPSC tab tom hloov pauv txoj kev tshawb fawb ntawm cov txheej txheem molecular ntawm cov kab mob vim nws muab txoj hauv kev los ua haujlwm ntawm tib neeg lub hlwb muab los ntawm cov neeg mob."
Magistretti ntxiv tias lub platform rau iPSC uas cov kws tshawb fawb KAUST tau tsim tso cai rau kev sib koom tes tshwj xeeb nrog cov chaw kho mob xws li KAU KAUH thiab nrog kev txhawb nqa ntawm KAUS KAUST Smart-Health Initiative Kev Pib Mus.
Cov txiaj ntsig tau los ntawm qhov kev tshawb fawb thawj zaug hauv Saudi no qhia pom tias muaj cov noob caj noob ces nyob ntawm X chromosome, uas nws qhov kev tswj hwm tshwj xeeb yog Klinefelter syndrome, tsis hais thaj chaw ntawm keeb kwm, haiv neeg thiab caj ces.
"Lub Saudi iPSC pawg no yuav ua haujlwm zoo tshaj plaws hauv xov tooj ntawm tes los tshawb nrhiav kev ua haujlwm ntxiv rau cov kab mob chromosomal," said. Antonio Adamo: koj puas xav tau ntau tus thwjtim?, tus kws tshaj lij thiab tus kws tshawb fawb tseem ceeb hauv Stem Cell thiab Diseases Laboratory ntawm KAUST.
"Piv txwv li, kev tsim qauv neurodevelopment thiab anatomical hloov pauv cuam tshuam rau cov teeb meem grey thiab dawb, cov yam ntxwv feem ntau pom hauv Klinefelter Syndrome yuav nthuav tshwj xeeb."
Lub platform cellular no yuav raug siv los tsim kom muaj lub npe hu ua "mini-brains," peb-dimensional kab lis kev cai ntawm cov neeg mob tau txais cov hlwb zoo li tib neeg lub hlwb uas tuaj yeem siv los kawm txog cov txheej txheem molecular hauv qab ntawm cov kab mob neurodevelopmental. Cov kev tshawb pom tau muab cov qauv hauv vitro tsim nyog rau kev tsim cov ntawv thov tshuaj tus kheej.
Tau qhov twg los: KAUS
koj ua tau muab koj qhov txuas mus rau ib nplooj ntawv uas muaj feem cuam tshuam rau lub ntsiab lus ntawm qhov kev tshaj tawm no.
