Tom Vandenkendelaere memba ne na Flemish Christian Democratic Party (CDV-EPP). Ya fara aikinsa na farko a Majalisar Tarayyar Turai daga 2014 zuwa 2019 kuma yanzu yana aiki na biyu har zuwa 2024. Daga 2012 har zuwa 2014 ya kasance Shugaban JONGCD&V - kungiyar matasa ta CD&V.