Kafukufuku waposachedwa wa mbewa wochitidwa ndi ofufuza a The University of Texas ku Dallas anapeza kuti kudya kwanthawi yochepa kwa zakudya zamafuta kwambiri kungagwirizane ndi zowawa zowawa, ngakhale popanda kuvulazidwa kale kapena chikhalidwe monga kunenepa kwambiri kapena shuga.
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Scientific Reports
Yakhazikitsidwa mu 2011, Scientific Report s ndi magazini yaikulu yasayansi yowunikiridwa ndi anzawo yofalitsidwa ndi Nature Portfolio, yofotokoza mbali zonse za sayansi ya chilengedwe. Mu Seputembala 2016, idakhala magazini yayikulu kwambiri padziko lonse lapansi yokhala ndi zolemba zambiri, kupitilira PLOS ON E.
” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]”>Scientific Reports, anayerekezera zotsatira za zakudya zosiyanasiyana pamagulu awiri a mbewa. Gulu limodzi linadyetsedwa chow chodziwika bwino, pamene lina linapatsidwa zakudya zopatsa mafuta kwambiri zomwe sizinapangitse kunenepa kwambiri kapena shuga wambiri wamagazi, zomwe zingayambitse matenda a shuga ndi mitundu ina ya ululu.
Ofufuzawa adapeza kuti kudya kwamafuta ambiri kunapangitsa kuti hyperalgesic priming - kusintha kwa minyewa komwe kumayimira kusintha kuchokera ku ululu wopweteka mpaka kupweteka - ndi allodynia, zomwe ndi zowawa zomwe zimabwera chifukwa cha zolimbikitsa zomwe sizimayambitsa ululu.
“Kafukufukuyu akusonyeza kuti simufunika kunenepa kwambiri kuti muyambitse ululu; simukusowa shuga; simufunikira matenda kapena kuvulala konse,” anatero Dr. Michael Burton, pulofesa wothandizira wa sayansi ya ubongo pa Sukulu ya Sayansi ya Makhalidwe ndi Ubongo komanso wolemba nkhaniyo. "Kudya zakudya zonenepa kwambiri kwa nthawi yochepa ndikokwanira - zakudya zofanana ndi zomwe pafupifupi tonsefe ku US timadya nthawi ina."
Dr. Michael Burton (kuchokera kumanzere), Calvin D. Uong, ndi Melissa E. Lenert adapeza kuti mtundu wina wa mafuta otchedwa palmitic acid umamangiriza ku receptor inayake pa maselo a mitsempha, njira yomwe imayambitsa kutupa ndi kutsanzira kuvulala kwa neurons. . Ngongole: Yunivesite ya Texas ku Dallas
Kafukufukuyu adayerekezanso mbewa zonenepa kwambiri, za matenda a shuga ndi omwe adangokumana ndi kusintha kwazakudya.
“Zinaonekeratu, modabwitsa, kuti simufunikira matenda kapena kunenepa kwambiri. Umangofunikira zakudya, ”adatero Burton. "Ili ndilo phunziro loyamba kusonyeza udindo wokhudzidwa wa nthawi yochepa ya zakudya zamafuta kwambiri ku allodynia kapena ululu wosatha."
Zakudya za kumadzulo zimakhala ndi mafuta ambiri - makamaka mafuta odzaza, omwe atsimikizira kuti amachititsa mliri wa kunenepa kwambiri, matenda a shuga, ndi zina zomwe zimagwirizanitsidwa nazo. Anthu omwe amadya mafuta ochulukirapo - monga batala, tchizi, ndi nyama yofiira - amakhala ndi mafuta ambiri aulere omwe amazungulira m'magazi awo omwe amayambitsa kutupa kwadongosolo.
Posachedwapa, asayansi asonyeza kuti zakudya zamafuta kwambirizi zimawonjezeranso kumva kupweteka kwa makina pakalibe kunenepa kwambiri komanso kuti zimatha kukulitsa zomwe zidalipo kale kapena kulepheretsa kuchira. Palibe maphunziro, komabe, omwe adalongosola momwe zakudya zokhala ndi mafuta ambiri zokha zimatha kukhala zochititsa chidwi poyambitsa ululu kuchokera kuzinthu zopanda ululu, monga kukhudza pang'ono pakhungu, adatero Burton.
"Tawona kale kuti, pamitundu ya matenda a shuga kapena kunenepa kwambiri, gawo limodzi lokha la anthu kapena nyama limakumana ndi allodynia, ndipo ngati litero, limasiyana mosiyanasiyana, ndipo sizikudziwika chifukwa chake," adatero Burton. . "Tinkangoganiza kuti payenera kukhala zinthu zina zomwe zimapangitsa kuti pakhale mpweya."
Burton ndi gulu lake adayang'ana mafuta odzaza mafuta m'magazi a mbewa zomwe zimadyetsedwa ndi zakudya zamafuta kwambiri. Iwo anapeza kuti mtundu wa mafuta
Asidi
Chilichonse chomwe chikasungunuka m'madzi, chimapereka pH kuchepera 7.0, kapena kupereka ayoni wa haidrojeni.
” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]”>asidi yotchedwa palmitic acid — asidi wochuluka wochuluka wamafuta azinyama pa nyama - amamanga ku cholandirira makamaka pama cell a mitsempha, njira yomwe imabweretsa kutupa ndikutsanzira kuvulala kwa ma neurons.
"Ma metabolites ochokera m'zakudya amayambitsa kutupa tisanawone matenda akukula," adatero Burton. "Chakudya chokhacho chinayambitsa zizindikiro za kuvulala kwa minyewa.
“Tsopano taona kuti ndi ma neuron amene amakhudzidwa, kodi zikuchitika bwanji? Tidazindikira kuti ngati mutachotsa cholandirira chomwe asidi a palmitic amamangirirako, simukuwona kukhudzidwa kwa ma neuron amenewo. Izi zikusonyeza kuti pali njira yoletsera mankhwala. ”
Burton adati sitepe yotsatira idzakhala kuyang'ana pa ma neuroni omwe - momwe amawathandizira komanso momwe kuvulala kwawo kungasinthire. Ndi mbali ya kuyesetsa kwakukulu kumvetsetsa bwino kusintha kuchokera ku ululu wopweteka mpaka kupweteka.
"Njira zomwe zimayambitsa kusinthaku ndizofunikira chifukwa ndikukhalapo kwa ululu wosatha - kuchokera kulikonse - zomwe zikuyambitsa mliri wa opioid," adatero. "Tikapeza njira yopewera kusinthaku kuchoka pamavuto kupita kwanthawi yayitali, zitha kuchita bwino kwambiri."
Burton adati akuyembekeza kuti kafukufuku wake amalimbikitsa akatswiri azaumoyo kuti aziganizira momwe zakudya zimathandizira pakuchepetsa ululu.
"Chifukwa chachikulu chomwe timachitira kafukufuku ngati chonchi ndi chifukwa tikufuna kumvetsetsa bwino za thupi lathu," adatero. “Tsopano, wodwala akapita kwa sing’anga, amamupatsa chithandizo malinga ndi matenda kapena matenda ake. Mwinamwake tiyenera kumvetsera kwambiri momwe wodwalayo anafikirako: Kodi wodwalayo ali ndi matenda a shuga kapena kunenepa kwambiri; Kodi zakudya zowopsa zawapangitsa kumva kuwawa kuposa momwe amaganizira? Kumeneko kungakhale kusintha kwa paradigm. "
Ndemanga: "Chakudya chamafuta ambiri chimayambitsa mechanical allodynia pakapanda kuvulala kapena matenda a shuga" ndi Jessica A. Tierney, Calvin D. Uong, Melissa E. Lenert, Marisa Williams ndi Michael D. Burton, 1 September 2022, Scientific Reports.
DOI: 10.1038 / s41598-022-18281-x
Kafukufukuyu adathandizidwa ndi National Institute of Diabetes and Digestive and Kidney Diseases, UT System STARS (Science and Technology Acquisition and Retention) pulogalamu, American Pain Society, ndi Rita Allen Foundation.
