Kufambira mberi kwezvino mu genome editing tekinoroji masayendisiti akagonesa masayendisiti kugadzirisa genomic sequences nekukurumidza uye nemazvo. Pasinei nekufambira mberi kwechimurenga munharaunda iyi, matambudziko mazhinji achiripo. Iripo iripo editing gene tekinoroji seCRISPR-cas9, base edhita uye maprime edhita vane mukana mukuru. Zvakadaro, matekinoroji ekutakura aripo haakwanise kuendesa matekinoroji ekugadzirisa majini kune akawanda anotangwa matissue uye maseru marudzi muhuwandu hwakakwana, izvo zvinotadzisa kukiriniki application. Nepo mamwe marudzi emasero, senge hepatocytes muchiropa, ane akawanda matekinoroji ekutakura anokwanisa kuendesa genome vapepeti, dzimwe nhengo dzakawanda nemhando dzemasero zvinonetsa kusvika.
Dambudziko makwikwi ezvikamu zvitatu:
MuChikamu 1, Vatori vechikamu vanozokumbirwa kuendesa chikumbiro chinotsanangura mhinduro yavo yakarongwa uye kuti ichagadzirisa sei zvinodiwa kune imwe yeTarget Areas. Vatori vechikamu vanogona kuendesa mhinduro kune ese ari maviri Nzvimbo Dzakatariswa asi vanofanirwa kuzviita nezvikumbiro zvakasiyana zvinogadzirisa zvakazvimiririra zvinodiwa neTarget Area imwe neimwe. Zvikumbiro zvinosvika gumi zvakatongwa kuti zvizadzise zvinodiwa zvinopihwa imwe neimwe inosvika zviuru makumi manomwe nezvishanu zvemadhora. Mibairo yekuwedzera ye $75,000 inogona kupihwa kune mamwe meritorious solutions zvichienderana neJudging Criteria.
MuChikamu chechipiri, Vatori vechikamu vanofanirwa kuendesa data kubva kuzvidzidzo zvinoratidza kuunza uye kugadzirisa mashandiro uye kutsanangura maitiro avo, tekinoroji, uye kuti mhinduro yavo inogadzirisa sei Dambudziko. Kutora chikamu muChikamu 2 hachisi chinhu chinodiwa kuti utore chikamu muChikamu 1; zvisinei, inokurudzirwa zvakasimba. Vanosvika gumi vanokunda muChikamu chechipiri vachapihwa mumwe nemumwe $2 uye vachakodzera kukwikwidza muChikamu chechitatu.
Chikamu 3 chakakamurwa kuita Chikamu 3a uye Chikamu 3b; vese vatori vechikamu vanofanirwa kuendesa mhinduro dzeChikamu 3a kuti vakwanise kutora chikamu muChikamu 3b. YeChikamu 3a, Vatori vechikamu vanofanirwa kuendesa ruzivo rwese rwunodiwa runoratidza kuti tekinoroji yavo yakagadzirira kuongororwa kwemhuka hombe kuburikidza neNIH-inotsigirwa yakazvimirira yekuongorora uye inogona kugadzirisa zvinodiwa kune imwe yeTarget Areas.
Kuendesa kune iyi Dambudziko kunofanirwa kugamuchirwa na12:00 AM EET, Ndira 11, 2025.
Source: Challenge.gov
