Bo-rasaense ba ile ba sibolla hore karolo ea bone ea lisele tse tsoetseng pele ka har’a testis li “bolaoa” ke li-phagocyte, ho sa tsotellehe hore lisele tsena ha li etse “phoso” leha e le efe.
Patlisiso ea Univesithi ea Haifa e khethile lisele tse bolaeang.
Ts'ebetso e amanang le "polao" ea lisele tse phelang, tse sa tsoa hlahisoa e fumanoe ka lekhetlo la pele lipatlisisong tsa morao-rao tse entsoeng Univesithing ea Haifa. Patlisiso, e hlalositsoeng koranteng e hlomphuoang Tsoelo-pele ea Saense, o ile a fumana hore ho pholletsa le ts'ebetso ea ho arohana ha lisele ho lintsintsi tsa litholoana, lisele tsa phagocytic li ja le ho senya lisele tse phelang tse phetseng hantle.
Re fumane hore li-phagocyte li ka sebetsa e le 'babolai.' Hoa tsebahala hore lisele tsa phagocytic li metsa le ho qhala lisele tse shoeleng, empa re bontša ka lekhetlo la pele hore li bolaea lisele tse tloaelehileng tse sa tsoa thehoa. Ha e le hantle re bontšitse mokhoa o mocha oa lefu la lisele. Ha re ntse re tseba haholoanyane mekhoa ea lefu la lisele, re utloisisa hamolemo mokhoa oa ho sebetsana ka katleho le mafu a sa tšoaneng, haholo-holo kankere ", ho hlalositse Moprofesa Hilla Toledano, hlooho ea Lefapha la Biology ea Batho Univesithing ea Haifa le mongoli oa thuto.
Tšimoloho ea lisele tse 'maloa tsa' mele, ho kenyeletsa letlalo, moriri, mpa le li-testicles, li ka 'na tsa saloa morao ho lisele tsa stem. Ka ho tsoela pele ho fana ka lisele tse ncha ho nkela tsa khale sebaka, lisele tsena tse matla tsa stem li etsa hore lisele li tlalehe hape. Seleng e 'ngoe le e' ngoe ea stem ts'ebetsong ena e arohana ho ba lisele tse peli, e 'ngoe ea tsona e bolokeloa ho sebelisoa nakong e tlang' me e 'ngoe e hōla ho nka sebaka sa sele e lahlehileng ka har'a lisele.
Phuputsong ea hajoale, Moprofesa Toledano, Moprofesa Estee Kurant, le sehlopha sa bo-rasaense ba tsoang Univesithing ea Haifa ba ile ba sheba lisele tsa thobalano tsa lintsintsi tsa litholoana. Kaha mekhoa e mengata ea limolek'hule ka lintsintsi tsa litholoana le batho li tšoana, li ka sebelisoa e le mohlala o atlehang boemong bona.
Lithuto tsa ho fofa ka litholoana li na le thuso ka lebaka la bokhoni ba ho beha leihlo lits'ebetso tsa lisele tse phelang le bonolo ba phetoho ea liphatsa tsa lefutso, e lumellang ho tsebahatsa hantle lits'ebetso tsa cellular. Ho 'nile ha fanoa ka likhau tse tšeletseng tsa Nobel ho theosa le lilemo ho bo-rasaense ba ileng ba sibolla mekhoa ea likokoana-hloko ho lintsintsi tsa litholoana tse bolokiloeng bathong.
Joalokaha ho boletsoe pejana, karohano ea stem cell ka lisele tse peli-stem cell le sele e tsejoang e le progenitor-e qala mokhoa oa ho khetholla li-sperms ho lintsintsi tsa litholoana tsa banna. Ts'ebetso ena e tsoela pele ho fihlela li-sperms tse sebetsang li thehoa. Bafuputsi ba ne ba se ba ntse ba tseba hore karolo ea bone ea lisele tsena tsa pele lia timela 'me ha li fetohe li-sperms tse tsoang lithutong tse fetileng. Sepheo sa thuto ea hona joale e ne e le ho utloisisa hamolemo se etsahalang ka lisele tsena.
'Mele o na le mokhoa o hlophisitsoeng hantle le oa bohlokoa o bitsoang lefu la lisele. Maemong a tloaelehileng, lisele li na le matla a ho “ipolaea” ha ho hlahile phetoho e khōlō kapa ka mor’a hore li phethe morero oa tsona. Li-phagocyte li tla ho "ja" lisele tse shoang, ka katleho li tlosa likahare tsa tsona le ho li qhaqha. Hoa tsebahala hore ka linako tse ling li-phagocyte li "ja" lisele tsa tsamaiso ea 'mele ea ho itšireletsa mafung tse qetileng mosebetsi oa tsona oa ho sireletsa' mele khahlanong le bahlaseli.
Phuputsong ea morao-rao, bafuputsi ba fumane hore li-phagocyte li "bolaea" kotara ea lisele tsa progenitor ka testis le hoja lisele tsena li sa etse letho "phoso" 'me li mpa li le mothating oa ho khetholla; e ntse e le lisele tse ncha 'me ha lia tloaeleha ka mokhoa oohle.
Mokhahlelong oa pele, bafuputsi ba ile ba thibela bokhoni ba ho ja ba phagocyte mme ba fumana lisele tse shoeleng liseleng. Ka mantsoe a mang, li-phagocyte li ikarabella bakeng sa lefu la lisele tsa pele.
Boemong ba bobeli, bafuputsi ba ile ba sebelisa litšoantšo tsa nako ea sebele ho shebella lisele tse phelang 'me ba fumana hore lisele tsa progenitor li metsoa li ntse li phela ke phagocyte, ebe joale ts'ebetso ea lefu e qala. “Ka lekhetlo la pele re ile ra fumana tšebetso e akarelletsang 'polao' ea lisele tse tloaelehileng ka ho feletseng. Re ntse re sa tsebe hore na ke hobane’ng ha sena se etsahala. Mohlomong ts'ebetso ena e ikemiselitse ho fana ka limatlafatsi ho boloka palo e sebetsang ea lisele tsa stem bophelo bohle ba sebōpuoa "Moprofesa Toledano o khothalelitse.
Ntle le kutloisiso ea mochine o mocha, thuto ena e ka kenya letsoho ho bokhoni ba rona ba ho hlahisa lithethefatsi le mekhoa ea ho laola lefu la lisele, haholo-holo, bakeng sa ho phekola mofetše. “Lihlahala li bonahala ka ho hōla ho sa khaotseng le ho sitisoa ha mokhoa oa tlhaho oa ho shoa ha lisele. Haeba re khona ho hlahisa phagocyte ts'ebetsong ena e khonang ho felisa lisele tsa mofetše tse phelang, re tla khona ho laola kholo ea hlahala. Ha re ntse re ithuta haholoanyane ka mekhoa ea lefu la lisele, re ka sebelisa mekhoa ena hamolemonyana ho ntša lisele tse nang le mofetše,” Moprofesa Toledano o ile a phetha ka ho re.
Reference: "The phagocytic cyst cell in Drosophila testis felisa germ cell progenitors via phagoptosis" ke Maayan Zohar-Fux, Aya Ben-Hamo-Arad, Tal Arad, Marina Volin, Boris Shklyar, Ketty Hakim-Mishnaevski, Lilach Porat-Kuperstein, Estee Kurant le Hila Toledano, 17 Phuptjane 2022, Tsoelo-pele ea Saense.
DOI: 10.1126/sciadv.abm4937
