Chifuwa ndi matenda omwe angapangitse kuti mpweya wanu ukhale wochepa komanso kutupa komanso kutulutsa mamina owonjezera.
M'malo mongochiza zizindikiro zake, njira yatsopano imayang'ana chimodzi mwazomwe zimayambitsa mphumu.
Ofufuza ochokera ku Aston University ndi
Dr. Jill Johnson, Sukulu ya Bioscience ya Aston University. Ngongole: Yunivesite ya Aston
Ku UK, pafupifupi anthu 1,200 amamwalira ndi mphumu chaka chilichonse, ndipo anthu ochepera 5.5 miliyoni amalandila chithandizo. Matenda a mphumu amabweretsa zizindikiro monga kupuma movutikira komanso kupuma movutikira chifukwa mpweya umakhala wokhuthala komanso wocheperako.
Mankhwala amakono, monga ma steroids, amapereka mpumulo kwakanthawi kuzizindikirozi mwa kumasula mpweya kapena kuchepetsa kutupa. Komabe, palibe mankhwala omwe alipo omwe amakhudza kusintha kwapangidwe komwe mphumu imayambitsa mumsewu ndi mapapo kuti athe kupereka chithandizo chokhalitsa.
Wofufuza wamkulu, Dr. Jill Johnson, wa ku Aston University's School of Biosciences, anati: "Poyang'ana kusintha kwa kayendedwe ka mpweya mwachindunji, tikukhulupirira kuti njirayi ikhoza kupereka chithandizo chokhalitsa komanso chothandiza kuposa zomwe zilipo kale, makamaka kwa odwala asthmatics omwe. musayankhe ma steroids. Komabe, ntchito yathu ikadali pachimake ndipo kafukufuku wina akufunika tisanayambe kuyesa izi mwa anthu. ”
Kafukufukuyu adayang'ana pamtundu wa cell stem yomwe imadziwika kuti pericyte, yomwe imapezeka makamaka m'mitsempha yamagazi. Pamene asthmatics ndi matupi awo sagwirizana ndi kutupa zimachitikira, monga ku nyumba nthata fumbi, ndi pericytes kusamukira ku airway makoma. Akafika kumeneko, ma pericytes amakhwima kukhala maselo a minofu ndi maselo ena omwe amakhuthala ndikuumitsa mayendedwe a mpweya.
Kuyenda uku kwa ma pericytes kumayambitsidwa ndi puloteni yotchedwa CXCL12. Ofufuzawo adagwiritsa ntchito molekyu yotchedwa LIT-927 kuti atseke chizindikiro kuchokera ku puloteniyi, poyilowetsa m'mitsempha ya mbewa. Makoswe a asthmatic omwe amathandizidwa ndi LIT-927 adachepetsa zizindikiro mkati mwa sabata imodzi ndipo zizindikiro zawo zidasowa mkati mwa milungu iwiri. Ofufuzawo adapezanso kuti makoma a mbewa omwe amathandizidwa ndi LIT-927 anali ochepa kwambiri kuposa omwe ali mu mbewa zosasamalidwa, pafupi ndi omwe amawongolera bwino.
Gululi tsopano likupempha ndalama zowonjezera kuti lichite kafukufuku wambiri pa mlingo ndi nthawi, Izi zingawathandize kudziwa nthawi yomwe ingakhale yabwino kwambiri yoperekera chithandizo panthawi yomwe matendawa akupita, kuchuluka kwa LIT-927 kumafunika, ndi kumvetsetsa bwino momwe mapapu amagwirira ntchito. Iwo amakhulupirira kuti ngati kafukufukuyu apambana, padutsa zaka zingapo kuti chithandizocho chikayesedwe mwa anthu.
Rebecca Bignold, Bushra Shammout, Jessica E. Rowley, Mariaelena Repici, Mariaelena Repici, John Simms ndi Jill R. Johnson, 12 July 13: Mankhwala Opuma.
DOI: 10.1186/s12931-022-02108-4
Kafukufukuyu adathandizidwa ndi Medical Research Council.
