Iiseli kunye neeseli ze-Immune zomzimba womntu zinokusabela njani ngokukhawuleza kutshintsho lomzimba kunye neekhemikhali kwindawo yazo?
Nangona ukuguqulwa kofuzo kunokubangela utshintsho kwiipropati zeseli, iindlela ezingezona zofuzo zinokuqhuba ukulungelelaniswa ngokukhawuleza, kwinkqubo ebizwa ngokuba yi-cell plasticity. Iplastiki yeseli ibandakanyeka kwiinkqubo zebhayoloji ezisisiseko kwi impilo kunye nesifo. Umzekelo, iiseli zethumba zinokusuka kwindawo eyandayo ziye kwindawo ehlaselayo, kwaye ngaloo ndlela zikhuthaze umhlaza wemetastasis. Ngakolunye uhlangothi, ngexesha lokuvuvukala, iiseli ze-immune ziyakwazi ukuguquka zibe ziiseli ezenza impendulo yokuvuvukala kunye nokukhuthaza ukulungiswa kwezicubu. Ukudumba okungalawulekiyo okuphuma esandleni kunokukhokelela ekonakaleni kwezicubu kwaye ekugqibeleni kukothuka kwe-septic.
Iqela kwi-Institut Curie eParis ngoku lifumene unobangela omtsha wezi nkqubo kwinqanaba le-molecular; umsebenzi opapashwe kutshanje kwijenali yenzululwazi indalo.
Abaphandi bafumanisa ukuba iiseli ezijongene nokwakhiwa kwe-metastasis okanye iiseli zokuzivikela ezithintekayo ekudumbeni kunye nokutshitshiswa kwamathandabuzo ziye zanda izixa zobhedu, ezijongene notshintsho kwiplastiki yeseli. Okubangela umdla kukuba, ikopolo ithathwa iye kwiiseli ngeprotheyini ebizwa ngokuba yi-CD44 kunye ne-hyaluronic acid, ekwaziwa ngokuba sisithako kwiimveliso ezininzi zobuhle. Besele kukho ubungqina bokuthathwa kwesinyithi yi-CD44 kwiiseli zomhlaza liqela lophando, elipapashwe ngaphambili kwijenali I-Nature Chemistry. I-CD44 yiprotheyini efundwe ngokubanzi amashumi eminyaka kwaye ifumaneka kwiindidi ezininzi zeeseli, eziquka iiseli zenkqubo yomzimba yokuzikhusela, iiseli zomhlaza, iiseli ezibandakanyekayo ekunyangeni amanxeba, iiseli zegazi ezibomvu nezinye ezininzi. Izazinzulu zibonise ukuba ubhedu oluthathwe yi-CD44 luqokelela kwi-mitochondria yeeseli, eziyi-organelles ezinoxanduva lokuvelisa amandla.
Ukuqhubela phambili umsebenzi wamapolisa ukuphanda iinkqubo ezisisiseko ziye zakhokelela kwiziphumo zokuba ubhedu lulawula i-metabolism kule mitochondria, okt ineempembelelo ezithe ngqo kwimveliso yamandla yeseli. Oku ke kutshintsha amanqanaba eemolekyuli ezibizwa ngokuba zii-metabolites, eziphembelela indlela imfuza efundwa ngayo kwiseli. Ngokukodwa amanqanaba e-NAD (H) achaphazelekayo, eyona nto iyaziwa kwaye ibaluleke kakhulu i-metabolites eyaziwayo kwiiseli zomntu. Ngamafutshane, olu tshintsho lunempembelelo into enokwenziwa yiseli kwaye ibukeke kwaye ichaphazele umsebenzi wayo.
Ngaphezu koko, izazinzulu zavelisa incinci entsha iziyobisi-njenge-molecule, esekelwe kwi-anti-diabetes drug metformin, enokuthi ithintele ezi nkqubo ngokubopha kunye nokungasebenzisi olu bhedu. Oku ke kuphembelela ukuveliswa kwamandla kweseli kwaye ekugqibeleni umsebenzi wayo. Kumxholo weeseli zokhuselo lomzimba, abaphandi banokufezekisa iiseli zomzimba ezinobundlongondlongo kwaye banciphise ukudumba kwiimodeli zempuku. Lo mzekelo mtsha wechiza unokuhlangula iimpuku zothuso lweseptic.
Kodwa kwakungaphelelanga apho. Uphononongo lukwabonise ukuba ezi nkqubo zisisiseko ezisisiseko sokudumba zikwafumaneka kumhlaza, ngakumbi kwiziganeko zemolekyuli ezinokubangela ukwakheka kwemetastasis! Ngaloo ndlela, le ndlela inokusetyenziselwa ukulwa ne-metastasis. Kuba ngaphezu kwe-11 yezigidi zabantu babulawa yi-septic shock ngonyaka kwaye i-90% yokufa komhlaza ngenxa ye-metastases, ngoku kukho ithemba elikhulu lokuba le nto inokuphuhliswa ibe ngamayeza amatsha, anokunceda izigulane ezininzi kwihlabathi jikelele.
Ngokubanzi, olu phononongo ngoku lubonisa isithembiso esikhulu, zombini kwinqanaba lophando olusisiseko semolekyuli kunye nezicelo zeklinikhi ezinokubakho. Ikwaphakamisa nombuzo wokuba lungakanani ubhedu olulunge kuthi?
Umthombo: Institut Curie
