Ukuguga kancinci ngokwebhayoloji: Abantu abahlala kufutshane neendawo eziluhlaza babeneminyaka eyi-2.5 bebancinci ngokwebhayoloji.
Izazinzulu zaseMntla-ntshona zenze uphando olutsha ukuze zibone ukuba ukuhlala kufuphi neendawo eziluhlaza, njengeepaki kunye neendawo ezinezityalo ezininzi, kunokuchaphazela indlela imizimba yethu eguga ngayo kwaye ibe negalelo ekugugeni okunempilo jikelele.
Ukuvezwa kweendawo eziluhlaza kwakunxulunyaniswa nokuguga okucothayo, ngokwengxelo yaseNorthwestern Medicine. Abantu ababehlala kufutshane neendawo eziluhlaza kakhulu ngokwebhayoloji babeneminyaka eyi-2.5 bebancinci, ngokwe-avareji, kunabo bahlala kufutshane nohlaza oluncinci. Umfanekiso wekhredithi: Kelly Sikkema nge-Unsplash, ilayisenisi yasimahla
Ngokwengxelo yaseNorthwestern Medicine, iindawo eziluhlaza ezingaphezulu zadityaniswa nokucotha ukuguga ngokwebhayoloji. Abantu ababehlala kufutshane neendawo eziluhlaza kakhulu ngokwebhayoloji babeneminyaka eyi-2.5 bebancinci, ngokwe-avareji, kunabo bahlala kufutshane nohlaza oluncinci.
Nangona kunjalo, izibonelelo zeendawo eziluhlaza azizange zilingane, njengoko izazinzulu zafumana ukuhluka kobuhlanga, isini kunye nesimo sentlalo zoqoqosho.
"Xa sicinga ngokuhlala sisempilweni njengoko sikhula, sidla ngokugxila kwizinto ezinjengokutya kakuhle, ukuzivocavoca kunye nokulala ngokwaneleyo," utshilo uKyeezu Kim, umbhali wokuqala kwisifundo kunye nomfundi we-postdoctoral kwiyeza lokuthintela kwiYunivesithi yaseNorthwestern University Feinberg School of. Iyeza.
"Nangona kunjalo, uphando lwethu lubonisa ukuba indawo esihlala kuyo, ngokukodwa uluntu lwethu kunye nokufikelela kwiindawo eziluhlaza, kubalulekile ukuba sihlale sisempilweni njengoko sikhula."
Ukuhlala kwindalo - ifoto ebonisa umfanekiso. Umfanekiso wekhredithi: Emma Simpson nge-Unsplash, ilayisenisi yasimahla
Uphononongo lolokuqala ukuphanda umphumo wokuvezwa kwexesha elide (malunga ne-20 iminyaka yokuvezwa) kwindawo eluhlaza edolophini kunye nokuguga kwezinto eziphilayo, ngokukodwa usebenzisa i-DNA methylation-based epigenetic age.
I-DNA methylation-based epigenetic age ibhekisela kutshintsho lweekhemikhali kwi-DNA ezinokuchaphazela iziphumo zempilo ezinxulumene nobudala. Ubudala be-Epigenetic yi-biomarker yokuguga ehambelana nesifo esinxulumene neminyaka kunye nokufa kwayo yonke into.
Abaphandi bafumene ukuhluka kwizibonelelo zeendawo eziluhlaza zokuguga kwebhayoloji ngokusekelwe kubuhlanga, isini kunye nesimo sentlalo zoqoqosho.
Uphononongo lubandakanya abantu abangaphezu kwama-900 abahlala kwizixeko ezine kulo lonke elase-US: eBirmingham, Ala.; eChicago; eMinneapolis; kunye ne-Oakland, Calif. Le sampuli imele i-subset ye-cohort enkulu yophando olwenziwe e-US, i-Coronary Artery Risk Development kwi-Young Adults (CARDIA).
Umbono womoya wesixeko. Umfanekiso wekhredithi: Chung Kevin ngePxhere, CC0 Domain Public
Abaphandi bavavanya ukuvezwa kweminyaka engama-20 kwiindawo ezingqongileyo eziluhlaza besebenzisa umfanekiso wesathelayithi, obavumele ukuba balinganise utyani ngokubanzi (ubungakanani bohlaza) kunye nobukho beepaki ezinkulu ezikufutshane neendawo zokuhlala zabathathi-nxaxheba. Ukuvavanya iminyaka yebhayoloji yabathathi-nxaxheba, izazinzulu zahlalutya igazi labo kwi-DNA methylation.
"Uphononongo lwethu lubonisa ukuba indawo yendalo, njengendawo eluhlaza, ichaphazela impilo yakho kwizinga le-molecular (utshintsho kwi-DNA methylation), efunyenwe egazini," watsho umbhali ophezulu uDkt. Lifang Hou, uprofesa weyeza lokuthintela eFeinberg.
“Iqela lethu lophando liphande ngokubanzi utshintsho lwemolekyuli ehambelana neziphumo ezahlukeneyo zempilo ezinxulumene nobudala, kubandakanya isifo sentliziyo, umhlaza, ukusebenza kwengqondo kunye nokufa. Olu phononongo luthile lunegalelo ekuqondeni kwethu ukuba indalo esingqongileyo ichaphazela njani ezi ziphumo zempilo.”
Ukungafani okubonwe kwisifundo esisekelwe kubuhlanga, isini kunye nesimo sentlalo zentlalo sigxininisa ukubaluleka kokuqhuba uphando lwexesha elizayo ukuphanda indima yentlalontle yempilo ngokumalunga nokusingqongileyo kunye nokuguga okunempilo, utshilo uHou.
"Sikholelwa ukuba iziphumo zethu zinefuthe elibalulekileyo lokucwangciswa kweedolophu malunga nokwandisa iziseko eziluhlaza ukukhuthaza impilo yoluntu kunye nokunciphisa ukungafani kwezempilo," kusho uKim.
umthombo: University
