Intuthuko yakamuva ku- ubuchwepheshe bokuhlela i-genome yenze ososayensi bakwazi ukulawula ukulandelana kwe-genomic ngokushesha nangempumelelo. Naphezu kwenqubekelaphambili yezinguquko kule ndawo, kunezinselelo ezimbalwa ezisekhona. Ubuchwepheshe bokuhlela obukhona obufana ne-CRISPR-cas9, abahleli abayisisekelo nabahleli abayinhloko banamandla amakhulu. Noma kunjalo, ubuchwepheshe obukhona bokulethwa abukwazi ukuletha ubuchwepheshe bokuhlela izakhi zofuzo ezicutshini eziningi eziqondiwe nezinhlobo zamaseli ngamanani anele, okuvimbela ukusetshenziswa komtholampilo. Nakuba ezinye izinhlobo zamaseli, njengama-hepatocyte esibindini, zinobuchwepheshe obuningi bokulethwa obukwazi ukuletha abahleli be-genome, ezinye izitho eziningi nezinhlobo zamaseli kunzima ukufinyelela kuzo.
Inselelo ingumncintiswano wezigaba ezintathu:
Esigabeni 1, Abahlanganyeli bazocelwa ukuba balethe isiphakamiso esichaza isisombululo sabo esihlongozwayo nokuthi sizobhekana kanjani nezidingo zenye Yezindawo Ezihlosiwe. Abahlanganyeli bangase bathumele izixazululo ezihlongozwayo kuzo zombili Izindawo Eziqondiwe kodwa kufanele benze kanjalo ngeziphakamiso ezihlukene ezibhekana nezimfuneko zendawo ngayinye eqondiwe. Iziphakamiso ezifika kweziyishumi ezahlulelwa ukuhlangabezana nezidingo ezihamba phambili zizonikezwa ngayinye efika ku-$75,000. Imiklomelo eyengeziwe ye-$50,000 ingase iklonyeliswe kwezinye izixazululo ezincomekayo ezisekelwe Kumbandela Wokwahlulela.
Esigabeni sesi-2, Abahlanganyeli kufanele balethe idatha evela ezifundweni ezibonisa ukusebenza kokulethwa nokuhlela futhi bachaze indlela yabo yokwenza, ubuchwepheshe, kanye nendlela isisombululo sabo esibhekana ngayo nemibandela Yokuphonselwa Inselelo. Ukubamba iqhaza kwiSigaba 1 akuyona imfuneko yokubamba iqhaza kwiSigaba sesi-2; nokho, ikhuthazwa kakhulu. Abawinile abangafika kwabayi-10 beSigaba sesi-2 bazoklonyeliswa ngamunye ngo-$250,000 futhi bazofaneleka ukuncintisana kuSigaba 3. Abawinile beSigaba 2 kuphela abazofaneleka ukubamba iqhaza kuSigaba sesi-3.
Isigaba sesi-3 sihlukaniswe ngeSigaba 3a kanye neSigaba 3b; bonke ababambiqhaza kufanele balethe izixazululo zeSigaba 3a ukuze bafaneleke ukubamba iqhaza kuSigaba 3b. Esigabeni sesi-3a, Abahlanganyeli kufanele bathumele lonke ulwazi oludingekayo olubonisa ukuthi ubuchwepheshe babo bulungele ukuhlolwa kwezilwane ezinkulu ngokuhlolwa okuzimele okusekelwe yi-NIH futhi bangaxazulula izidingo zenye Yezindawo Ezihlosiwe.
Okuthunyelwe kule nselelo kufanele kwamukelwe ngo-12:00 AM EET, Januwari 11, 2025.
Source: Challenge.gov
